Topic: Immunomodulation
Title: CORRELATION BETWEEN ACUTE AND CHRONIC INFLAMMATORY STATES, A CASE CONTROL STUDY
Seema Mahesh*, Mahesh Mallappa, Vitalie Vacaras, Viraj Shah, Amritha Belagaje, Pooja Dhamodar, Elena Serzhantova, Nadezhda Kubasheva, Dmitriy Chabanov, Dionysios Tsintzas, Latika Jaggi, Atul Jaggi, George Vithoulkas.
Presenting author:
1 Seema Mahesh
School of Medicine, Faculty of Health and Medical Sciences, Taylor’s University, Malaysia
Centre For Classical Homeopathy, Bangalore, India
Tel: +91 9449084747
Author and co-author’s details:
2 Mahesh Mallappa
Centre for Classical Homeopathy, Bangalore, India
3 Vitalie Vacaras
Department of Neurosciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
4 Viraj Shah
Shah Homeopathic Clinic, Vastrapur, Ahmedabad, India
5 Amritha Belagaje
Centre for Classical Homeopathy, Bangalore, India
6 Pooja Dhamodar
Centre for Classical Homeopathy, Bangalore, India
7 Elena Serzhantova
Novosibirsk Centre of Classical Homeopathy, Novosibirsk, Russia
8 Nadezhda Kubasheva
Clinic of Nadezhda Kubasheva, Moscow Russia
9 Dmitriy Chabanov
Novosibirsk Centre of Classical Homeopathy, Novosibirsk, Russia
10 Dionysios Tsintzas
General Hospital of Aitoloakarnania, Agrinion, Greece
11 Latika Jaggi
H3 Centre of Classical Homeopathy, Nashik, India
12 Atul Jaggi
H3 Centre of Classical Homeopathy, Nashik, India
13 George Vithoulkas
University of the Aegean, Syros, Greece
Postgraduate Doctors’ Training Institute, Health Care Ministry of the Chuvash Republic, Cheboksary, Russian Federation
Preferred Presentation type: Oral presentation
Background and aim:
Suppression of efficient acute inflammation may be one of the mechanisms behind the onset of chronic low-grade inflammation. Efficient acute inflammatory response to pathogenic stimulus may not be possible in the presence of chronic inflammation. We investigated if a correlation exists between chronic and efficient acute inflammation.
Methods:
Design: Case control study.
Setting: Homeopathic medical practices in 4 countries
Patients with definite improvement in chronic inflammatory conditions with at least 6 months of follow up were selected as cases. Age matched controls involved those who did not improve.
Event of interest: Occurrence of common acute infectious diseases with fever during the follow up period.
Statistical analysis: Odds Ratio of improvement in the chronic condition, with development of acute infectious diseases with fever was calculated.
Graphs were plotted to study this correlation in individual cases.
Results:
20 cases and 20 age matched controls were selected. Average age was 28.4 and 27.9 years respectively. 18/20 cases and 4/20 controls developed common infectious diseases with fever during the follow up period. Odds Ratio of the chronic condition improving, with development of acute infectious diseases with fever was 36 (95 %, CI: 5.7973 to 223.5513), z statistic: 3.846 and significance level was p = 0.0001.
Graphs of individual cases showed distinct patterns confirming the same.
Conclusions:
In this case control study, appearance of common acute infectious diseases with fever during treatment was strongly associated with improvement in the chronic inflammatory conditions. Larger studies are needed to further establish the correlation.