(Phenazone-A Coal-tar Derivative) Antipyrine is one of the drugs that induce leucocytosis, similar to ergotin, salicylates, and tuberculin. Acts especially on the vaso-motor centers, causing dilation of capillaries of skin and consequent circumscribed patches of hyperaemia and swelling. In large doses causes profuse perspiration, dizziness, cyanosis, and somnolence, albumen and blood in urine. Acute erythema multiforme.
Mind
Fear of becoming insane; nervous anxiety; HALLUCINATIONS OF SIGHT AND HEARING.
Head
Throbbing headache; SENSATION OF CONSTRICTION. Flashes of heat. HEADACHE UNDER EARS WITH EARACHE.
Eyes
Puffiness of lids. Conjunctiva red and oedematous, WITH LACHRYMALION. Red spots. (APIS.)
Ears
Pains and buzzing. TINNITUS.
Face
Oedema and puffiness. Red and swollen.
Mouth
Swelling of lips. Burning of mouth and gums. Ulceration of lips and tongue; vesicles and bullae. Small lump in cheek. Tongue swollen. Bloody saliva. Toothache along lower jaw. Throat. Pain on swallowing. Expectoration of fetid pus. Abscess, white false membrane. Sensation of burning.
Stomach
Nausea and vomiting; burning and pain. Urine. Diminished. Penis black.
Female
Itching and burning in vagina. Menses suppressed. Watery leucorrhoea.
Respiratory
Fluent coryza. Nasal mucous membrane swollen. Dull pains in frontal sinus. Aphonia. Oppression and dyspnoea. Cheyne-Stokes respiration.
Heart
Faintness, with sensation of stoppage of heart. Throbbing throughout the body. Rapid, weak, irregular pulse. Nerves. Epileptiform seizures. Contractures. Trembling and cramps. Crawling and numbness. GENERAL PROSTRATION.
Skin
ERYTHEMA, eczema, pemphigus. INTENSE PRURITUS. URTICARIA, appearing and disappearing suddenly, with internal coldness. Angioneurotic-oedema. Dark blotches on skin of penis, sometimes with oedema.
Dose
Second decimal potency.