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Materia Medica Viva Volume 9 – page 2015

Emotions, especially vexation, anger, and mortifica¬tion, will aggravate. They are apt to excite many different complaints. Margaret Tyler writes about one of her patients who had tremendous attacks of pain: ‘Whenever she becomes excited, an attack occurs’.
Eating and drinking, even of the slightest quantities, will aggravate in most cases, for instance in dysmenorrhoea, in diarrhoea, in colic etc. On the other hand, motion will often tend to relieve (which is, however, not always the case), because the pains are frequently coupled with a tremendous restlessness. External warmth will usually ameliorate a little.
Aggravation of symptoms at 4 pm (Lycopodium). Colicky pain and neuralgia tend to occur or increase at that time. For instance, ‘terrible, contractive, twisting pains in bowels, imme¬diately about umbilicus’ occurred at 4 pm on six days, and a cutting pain ‘as from a chisel’ in abdomen also began at that time. In a cured case, sciatica recurred periodically at 4 pm.
Incidentally, the provings also show that several provers had diarrhoeic stools at 4 pm, with relief of abdominal pain. This is another confirmation for this time of day as a Colocynthis pointer.
Guernsey mentions (in his Keynotes) an aggravation by urination. This modality is deduced from a proving symptom: ‘Sensation of violent pressure in the left temple, worse when urinating’. If such an aggravation is observed in painful states, Colocynthis should be thought of.
The remedy tends to prefer the left side of the body; neuralgic states tend to appear left-sided.